With continuing advances in metabolomics along with constant user feedback, it became clear that a substantial upgrade to the original server was necessary. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.ĭownloaded from by guest on June 2, 2016įirst released in 2009, MetaboAnalyst (was a relatively simple web server designed to facilitate metabolomic data processing and statistical analysis. *To whom correspondence should be addressed. This has led to numerous requests by users to simplify its interface, to improve the graphics, to accelerate the calculations and to provide more user support. As the popularity of MetaboAnalyst has grown, so too has its use by non-experts or statistically naı¨ ve users. Other obvious trends in metabolomic data analysis include: (i) a greater demand for tools to support time-series analysis, (ii) a growing need to support the statistical analysis of more complex experimental designs (8) and (iii) requests to offer more stringent evaluation of the results generated from chemometric analyses (9). Likewise, with increasing numbers of large-scale metabolomic studies being performed, the need for data quality control (QC) and quality assessment support has become much more apparent (6,7) and much more frequently requested by MetaboAnalyst users. For instance, as more and more metabolomics researchers adopt quantitative or targeted metabolomic approaches (2–5), requests by our users for improved methods to perform functional or biological interpretation have continued to grow. However, the rapidly changing nature of metabolomics (both in terms of the technology and the experimental design) has meant that some of the analytical and graphical components in the original version of MetaboAnalyst have become outdated, insufficient or inadequate. To date it has served more than 10 000 researchers from nearly 1500 different institutions. As the first dedicated web server for metabolomic data processing, MetaboAnalyst quickly gained considerable traction within the metabolomics community. INTRODUCTION MetaboAnalyst is a web-based suite for high-throughput metabolomic data analysis. Received FebruRevised ApAccepted April 12, 2012 Wishart1,2,4,* 1 4ĭepartment of Biological Sciences, 2Department of Computing Science, 3Department of Medicine and National Research Council, National Institute for Nanotechnology (NINT), Edmonton, AB, Canada T6G 2E8 Sinelnikov2, David Broadhurst3 and David S. MetaboAnalyst 2.0-a comprehensive server for metabolomic data analysis Jianguo Xia1, Rupasri Mandal2, Igor V.
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